NinjaLA made this pretty nifty sketch inspired by the Raptor heavy fighter. He started with the familiar bones of the craft and then started filling in the connections in a radical way. There's a careful balance of authenticity and artistic license necessary, but it seems like this technique could be applied to a number of ships with wild results!
I have been experimenting with different blocking methods. I think this works fairly well. Throw down some two or three tone shapes and just start throwing lines in where it looks like they'd be.