I wonder if you really want a nuclear missile that explodes based only on proximity in the middle of a pitched space battle... it might be fine for shooting off at an enemy formation at the start of an engagement, but anywhere else you run the risk of hurting friendlies.
I don't know if there would be such a big problem with the brass. There have been at least two nuclear air-to-air missiles that I know of, the unguided Genie and a variant of the radar-guided Falcon.
They were carried by interceptors and were meant to take down entire bomber formations.
I can definitely imagine a Wasp being armed with a Mace II or whatever follow on nuke there might be.