Please write your exact error message, your Windows version, along with the configuration you used in the options and your video card brand please.
If you use an ATI, it has problems with the 32-bits patch. Just select 16-bits mode and see if it works. If it does, you can try to fix 32-bit mode with a special DLL we supplied with the installation. Just rename gl_0000x.ati into gl_0000x.dll (backup the original gl_0000x.dll first) and see if it fixes 32-bits mode for you.
If you don't have an ATI video card, well post us as many information as you can and we'll try to help you.