I ran WC2 without using moslo just fine (for the most part). The combat was just fine, and the cutscenes were okay, although I had to read really fast (especially on the ones with the Kilrathi, oddly enough). Of course, this was running with no sound. I really can't remember how I was able to run it, though, and I don't have it installed at the moment. I think a DOS-mode shortcut with EMS enabled worked, but I can't remember for certain.