The Antares Quadrant lies in the Epsilon Sector and consists of the Antares, Bistangio, Charon, Circe, Corsair, D'vd Tang, Firekka, Granita, K'k-Tahn, K'ta Mek, Khar Takh, Khar-Sa, Midgard, N'Tanya, S'thran-Pak, Shariha, Sharm, T'kirsa, Tau Ceti, Trafalgar, Tv'x Aq, Veratek, Veronica and Yarin systems.
The Antares Quadrant saw extensive action during the Terran-Kilrathi War. From 2655 to 2656, the Terran Confederation fought the Kilrathi Empire when the later invaded Firekka. The siege eventually ended in a Terran-Firekkan victory, and it severely weakened the Kilrathi's claim on the quadrant. A lot of fighting took place at Charon during this battle as well.
Since the failure of the Firekka invasion, the Kilrathi planets of Shariha and N'Tanya have seceded from the Empire and joined the Terrans. In 2669, Trafalgar was wiped out with biological weapons, and Bistangio was left in ruins in a surprise attack. After the war ended, Circe saw itself in the midst of a brutal civil war in 2673. Finally, in 2678, the Firekkan Planetary Alliance was formed, and now consists of both Firekka and T'kirsa.
In the Wing Commander I video game, the Antares Quadrant is erroneously referred to as the "Antares Sector" in the ending scene of "Secret Missions II".